Immune Repertoire Insights That Advance Precision Medicine

Unveil the adaptive immune response with TCR/BCR profiling and single-cell paired-chain V(D)J analysis for biomarker discovery and therapeutic development

Resolve patient-specific immune signals for cancer, autoimmunity, infectious disease, and more.

Immune repertoire sequencing provides insights into immune history and diversity, neutralizing antibodies, antigen specificity, and clonal dynamics with the potential to transform overall management of immune-mediated diseases and therapies.

Standard immune repertoire sequencing approaches are limited by subtype restrictions, lack of reproducibility, high error rates, insufficient capture of rare clones, and limited data analysis tools for mapping repertoire diversity and clonality networks.

See why iRepertoire is the most trusted and comprehensive source for immune enlightenment.

Full-stack immune profiling expertise:
From sensitive detection to rich data analysis

We offer a complete suite of adaptive immune receptor profiling and data analysis solutions. Each platform workflow combines proprietary chemistry with optimized analytics to reveal the true diversity of the adaptive immune system.

Bulk TCR/BCR Sequencing with Full 7-Chain Coverage

While other platforms require multiple reactions to profile different receptor chains or limit analysis to DNA or RNA alone, iRepertoire’s dam-PCR technology simultaneously amplifies all seven chains (TCR⍺, TCRβ, TCR𝛾, TCRδ, IgH, IgK, IgL) with UMI-based error correction. The unique capability delivers the complete immune picture your research demands, without compromising on sensitivity or amplification bias.

Single-Cell V(D)J Sequencing

Capture therapeutically relevant cognate TCR or BCR pairing from FACS-isolated single cells with our iPair platform, designed for researchers who need full-length, physically paired sequences without investing in expensive single-cell platforms.

Data Analysis

We’ve analyzed immune repertoires since 2009, publishing landmark studies and supporting dozens of clinical programs. Our scientists don’t just generate data; they partner with you to extract biological meaning and accelerate decision-making.

Bulk TCR/BCR Sequencing with Full 7-Chain Coverage

While other platforms require multiple reactions to profile different receptor chains or limit analysis to DNA or RNA alone, iRepertoire’s dam-PCR technology simultaneously amplifies all seven chains (TCRa, TCRB, TCRy, TCR6, IgH, IgK, IgL) with UMI- based error correction. The unique capability delivers the complete immune picture your research demands, without compromising on sensitivity or amplification bias.

Single-Cell V(D)J Sequencing

Bioinformatics

Precise, cost-effective insights with published validity
across key clinical areas

Our immune repertoire profiling solutions empower discovery, preclinical, and clinical teams across therapeutic areas. See how we enable confident biomarker identification and therapeutic development for each.

Immuno-oncology Therapy Monitoring

Comprehensive TCR/ BCR repertoire and gene expression insights to track treatment response, reveal biomarkers of efficacy or toxicity, and support data-driven clinical decisions.

Cell Therapy Optimization

Cell therapy optimization and quality control with multi-omic immune profiling that validates manufacturing consistency, confirms therapeutic phenotype, and de-risks clinical development.

Infectious Disease Therapeutics

Advance infectious disease therapeutics by mapping rare antigen-specific B- and T-cell responses, defining host immune signatures, and guiding the discovery of vaccines and monoclonal antibodies.

Autoimmune Disease Biomarker Discovery

Uncover autoimmune disease biomarkers by profiling rare B and T-cell clones and immune repertoires-delivering reproducible insights into disease mechanisms, diagnostics, and treatment response prediction.

The iRepertoire difference

Founded by immunologists for immunologists at HudsonAlpha Institute for Biotechnology, we’ve never forgotten that behind every sample is a scientific question that matters. Our technology is sophisticated, but our approach is simple: deliver the most complete, accurate immune profiling data possible, and partner with you to extract biological meaning. Our three main core values set us apart from other companies as we strive to create true partnerships with our customers.

Scientific Partnership, Not Just Service

Dedicated PhD-level scientists review every project from library prep through data delivery
Custom assay optimization for your specific research questions
Collaborative data interpretation and publication support

Quality You Can Defend

GCLP-compliant Quality Management System
Batch-level QC with contamination detection and flagging
Replicate controls in every run for absolute confidence
Validation documentation ready for regulatory submissions

Flexibility That Accelerates Discovery

Adapt protocols mid-study as your questions evolve
Scale from pilot studies to pivotal trials seamlessly
Support for non-standard sample types and experimental designs

iRepertoire has been the scientists’ choice for immune repertoire analysis, offering accuracy, reproducibility, and actionable insights. We have partnered with top institutions to develop the next generation of immune-based biomarkers and therapeutics. Explore who our partners are or read our publications to learn more about our contributions.

Customer Testimonials

"The best features of iRepertoire's service are the custom repertoire analytics and applications for multiple research projects and models."

"I would recommend iRepertoire's services based on the ability to modify and customize the sequencing process to a researcher's needs."

"iRepertoire's expertise is great. Having those conversations where we can ask specific technical questions and be able to better understand the science of the process is very helpful."

"iRepertoire's technology is really customizable from start to finish. I would certainly call iRepertoire a very close collaborator."

"We chose iRepertoire because they have a solution for rare cell types and experience that none of the other competitors do."

Immune Repertoire Insights That Advance Precision Medicine

Resolve patient-specific immune signals for cancer, autoimmunity, infectious disease, and more.

Full-stack immune profiling expertise:
From sensitive detection to rich data analysis

Bulk TCR/BCR Sequencing with Full 7-Chain Coverage

Single-Cell V(D)J Sequencing

Data Analysis