Services Overview
Facilitating immune repertoire research with comprehensive single-cell and bulk sequencing.
Key Applications
Immuno-Oncology
- Identify novel signatures when comparing pre- and post-treatment samples
- Identify expanded TCRs
- Identify neo-epitope specific TCRs from primary tumor cells
- Characterize uniformity of manufactured cell products
Infectious Disease
- Identify low frequency antigen-specific B cells
- Characterize host response
- Identify infection signatures with prognostic utility
- Capture rare effector B cells for therapeutic antibody development
Services Overview
Sample Preparation
Send iRepertoire your nucleic acids, bulk cells, tissue, or whole blood samples for bulk repertoire analysis of human or mouse cells. For single cell services, cell sorting can be performed either in your lab or at iRepertoire by our experienced FACS team. Learn more about how to prepare your samples here.
Amplification
Amplification with our patented technology.
Sequencing
Sequencing is performed on Illumina platforms and can be individualized to your needs. Learn more about our sequencing services here.
Data Analysis
All RepSeq, RepSeq+, and iPair services come with complimentary basic analysis, viewable by either iRweb or the iPair Analyzer.
Which Assay is Right for Me?
Bulk Repertoire
Discover the diversity in the expressed immune repertoire of TCR and BCR chains with our full-service RepSeq and RepSeq+ solutions.
- We recommend RepSeq for discovering rare clonotypes with low cell counts
- We recommend RepSeq+ for applications requiring high error detection
Single Cell
Our iPair and iPair+ solutions provide critical data on the physical cognate pairing of TCR or BCR chains within a single cell.
- We recommend iPair as our core single-cell immune sequencing service
- We recommend iPair+ for enhanced phenotypic analysis of single immune cells